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ID: ALA1144339
Journal: Bioorg Med Chem Lett
Title: Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation.
Authors: Zhang Y, Li JX, Zhao J, Wang SZ, Pan Y, Tanaka K, Kadota S.
Abstract: Two series of oleanolic acid derivatives were synthesized and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha,25-dihydroxy vitamin D3 was evaluated in a co-culture assay system. The structure-activity relationships, together with electronic structure based on the frontier molecular orbitals, for example, HOMO and LUMO, related to different amino acid substituents were studied. Derivatives with proline or phenylalanine showed a tendency to enhance the inhibitory activity.
CiteXplore: 15745811