Basic Information
ID: ALA1144374
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.
Authors: Paterson I, Menche D, Håkansson AE, Longstaff A, Wong D, Barasoain I, Buey RM, Díaz JF.
Abstract: Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
CiteXplore: 15837302
DOI: 10.1016/j.bmcl.2005.03.018
Patent ID: ┄
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