Document Report Card

ID: ALA1144399

Journal: J Med Chem

Title: Peptoid-peptide hybrids as potent novel melanocortin receptor ligands.

Authors: Kruijtzer JA, Nijenhuis WA, Wanders N, Gispen WH, Liskamp RM, Adan RA.

Abstract: All possible peptoid-peptide hybrids of an MC4 receptor agonist were synthesized and investigated on cells expressing different melanocortin (MC) receptor subtypes and for rat grooming behavior. In general, receptor selectivity remained while affinity and potency were decreased. The length of the functional group of Trp was more important for MC3 and MC5 than for MC4 receptor binding. In general, the potency of the peptoid-peptide hybrids to increase rat excessive grooming behavior correlated well with MC4 receptor pharmacology.

CiteXplore: 15974575

DOI: 10.1021/jm0490033