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ID: ALA1144436
Journal: Bioorg Med Chem Lett
Title: 1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.
Authors: Jiang JK, Thomas CJ, Neumann S, Lu X, Rice KC, Gershengorn MC.
Abstract: We report the synthesis of and binding to the two subtypes of mouse thyrotropin-releasing hormone (TRH) receptors, TRH-R1 and TRH-R2, of several 1-(phenyl)isoquinoline carboxamide analogues. These analogues showed a degree of selectivity for binding at TRH-R2. These are the first ligands reported that show selective binding to these receptors.
CiteXplore: 15664847