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ID: ALA1144542
Journal: Bioorg Med Chem
Title: Design of endoperoxides with anti-Candida activity.
Authors: Avery TD, Macreadie PI, Greatrex BW, Robinson TV, Taylor DK, Macreadie IG.
Abstract: Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
CiteXplore: 17079152