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ID: ALA1144556
Journal: Bioorg Med Chem
Title: Design, synthesis, and SAR analysis of novel selective sigma1 ligands.
Authors: Collina S, Loddo G, Urbano M, Linati L, Callegari A, Ortuso F, Alcaro S, Laggner C, Langer T, Prezzavento O, Ronsisvalle G, Azzolina O.
Abstract: A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.
CiteXplore: 17088069