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ID: ALA1144582

Journal: Bioorg Med Chem Lett

Title: Identification of arylsulfonamides as Aquaporin 4 inhibitors.

Authors: Huber VJ, Tsujita M, Yamazaki M, Sakimura K, Nakada T.

Abstract: Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.

CiteXplore: 17178220

DOI: 10.1016/j.bmcl.2006.12.010