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ID: ALA1144583
Journal: Eur J Med Chem
Title: Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.
Authors: Kumar A, Singh BK, Sharma NK, Gyanda K, Jain SK, Tyagi YK, Baghel AS, Pandey M, Sharma SK, Prasad AK, Jain SC, Rastogi RC, Raj HG, Watterson AC, Van der Eycken E, Parmar VS.
Abstract: The earlier work carried out in our laboratory led to the identification of a novel rat liver microsomal enzyme termed as acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates (PA) to functional proteins. In this paper, we have reported the comparison of the specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones with special reference to the phenyl moiety/bulky group on the pyran ring of PA. The results clearly indicated that compounds having phenyl moieties, when used as the substrates, resulted in a significant reduction of TAase catalyzed activity. The alteration in TAase catalyzed activation of NADPH cytochrome c reductase and inhibition of benzene-induced micronuclei in bone marrow cells by PA were in tune with their specificities to TAase.
CiteXplore: 17182154