Document Report Card
Basic Information
ID: ALA1144617
Journal: Bioorg Med Chem Lett
Title: Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.
Authors: Zhang L, Qiu B, Xiong B, Li X, Li J, Wang X, Li J, Shen J.
Abstract: A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in humans associated with dysfunctional Jnk signaling.
CiteXplore: 17303416