Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.

Basic Information

ID: ALA1144654

Journal: Bioorg Med Chem Lett

Title: Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.

Authors: Zhao H, Serby MD, Smith HT, Cao N, Suhar TS, Surowy TK, Camp HS, Collins CA, Sham HL, Liu G.

Abstract: A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.

CiteXplore: 17434733

DOI: 10.1016/j.bmcl.2007.03.099

Patent ID: ┄