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ID: ALA1144658

Journal: Bioorg Med Chem Lett

Title: Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.

Authors: Johnson M, Li AR, Liu J, Fu Z, Zhu L, Miao S, Wang X, Xu Q, Huang A, Marcus A, Xu F, Ebsworth K, Sablan E, Danao J, Kumer J, Dairaghi D, Lawrence C, Sullivan T, Tonn G, Schall T, Collins T, Medina J.

Abstract: A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a (125)I-IP10 displacement assay and in in vitro cell migration assays to IP10, ITAC, and MIG using human peripheral blood mononuclear cells.

CiteXplore: 17448658

DOI: 10.1016/j.bmcl.2007.03.106