Document Report Card
Basic Information
ID: ALA1144674
Journal: Bioorg Med Chem
Title: Synthesis and pharmacological activity of aminoindanone dimers and related compounds.
Authors: Sheridan H, Butterly S, Walsh JJ, Cogan C, Jordan M, Nolan O, Frankish N.
Abstract: A series of N-substituted 3-aminoindanones were synthesised and evaluated for smooth muscle relaxant activity and mediator release inhibition effects. A low level of smooth muscle relaxant activity has been identified in all derivatives. Data have revealed that the significant mediator release inhibition effects observed are related to the nature of the amine substituents. A structure activity relationship is proposed.
CiteXplore: 17936628