Document Report Card

ID: ALA1144721

Journal: J Nat Prod

Title: Bioactive triterpene saponins from the roots of Phytolacca americana.

Authors: Wang L, Bai L, Nagasawa T, Hasegawa T, Yang X, Sakai J, Bai Y, Kataoka T, Oka S, Hirose K, Tomida A, Tsuruo T, Ando M.

Abstract: Five new triterpene saponins named phytolaccasaponins N-1 (1), N-2 (2), N-3 (3) N-4 (4), and N-5 (5) were isolated from the roots of Phytolacca americana together with seven known triterpene saponins (6-12). The structures of the five new saponins were established as shown in structures 1-5 on the basis of their spectroscopic data. The MDR-reversal activity of 1-12 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780 AD cells in the presence of each compound. The most effective compound was 8 (155% of control at 25 microg/mL).

CiteXplore: 18177012

DOI: 10.1021/np078012m