Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Basic Information

ID: ALA1144745

Journal: Bioorg Med Chem Lett

Title: Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Authors: Starck JP, Provins L, Christophe B, Gillard M, Jadot S, Lo Brutto P, Quéré L, Talaga P, Guyaux M.

Abstract: SAR around alkyne-quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.

CiteXplore: 18359633

DOI: 10.1016/j.bmcl.2008.03.024

Patent ID: ┄