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ID: ALA1144791
Journal: Bioorg Med Chem Lett
Title: Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
Authors: Gooden DM, Schmidt DM, Pollock JA, Kabadi AM, McCafferty DG.
Abstract: A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
CiteXplore: 18242989