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ID: ALA1144953
Journal: Bioorg Med Chem Lett
Title: Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.
Authors: Ishioka T, Tanatani A, Nagasawa K, Hashimoto Y.
Abstract: Anti-androgens were designed based on the principle of inhibiting the folding of helix 12 of the nuclear androgen receptor. The prepared anti-androgens exhibited full antagonistic activity toward human prostate tumor LNCaP cells with T877A point-mutated nuclear androgen receptor, as far as examined, towards which other known anti-androgens, including hydroxyflutamide, are inactive or act as androgen agonists.
CiteXplore: 12873487