Stereoselective synthesis of beta-lactams with polyaromatic imines: entry to new and novel anticancer agents.
Basic Information
ID: ALA1145010
Journal: J Med Chem
Title: Stereoselective synthesis of beta-lactams with polyaromatic imines: entry to new and novel anticancer agents.
Authors: Banik I, Becker FF, Banik BK.
Abstract: We present herein stereoselective synthesis of novel beta-lactams using polyaromatic imines following the Staudinger reaction. Consistent mechanisms for these results have been advanced. As a measure of cytotoxicity, some of these compounds have been assayed against nine human cancer cell lines. Structure-activity study has revealed that 1-N-chrysenyl and 1-N-phenanthrenyl 3-acetoxy-4-aryl-2-azetidinones have potent anticancer activity. The presence of the acetoxy group at C(3) of the beta-lactams has proven to be obligatory for their anticancer activity.
CiteXplore: 12502355
DOI: 10.1021/jm0255825
Patent ID: ┄