Document Report Card

ID: ALA1145046

Journal: J Med Chem

Title: Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.

Authors: Cappelli A, Pericot Mohr Gl, Gallelli A, Giuliani G, Anzini M, Vomero S, Fresta M, Porcu P, Maciocco E, Concas A, Biggio G, Donati A.

Abstract: The structure-activity relationship studies on 2-quinolinecarboxamide peripheral benzodiazepine receptor (PBR) ligands have been refined with the aim of using these ligands as carriers of radionuclides and boron atoms. Some new ligands show enhanced affinity and steroidogenic activity with respect to reference compound 1 and are interesting candidates for radiolabeling and PET studies. Moreover, carborane derivative 3q, representing the first example of PBR ligand bearing a carborane cage, can be useful to explore an alternative mechanism in BNCT.

CiteXplore: 12904061

DOI: 10.1021/jm034068b