Document Report Card

ID: ALA1145048

Journal: J Med Chem

Title: Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells.

Authors: Hanessian S, Zhan L, Bovey R, Saavedra OM, Juillerat-Jeanneret L.

Abstract: The effects of functionalized aryl beta-D-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by these molecules in human glioblastoma cells. Inhibition of DNA synthesis precedes induction of apoptosis and growth inhibition. The substituents at C-1, C-2, C-3,C-4, and C-6 on the pyranosidic scaffold are important to modulate the action and the efficacy of these molecules. Human fibroblasts and brain-derived endothelial cells were less sensitive to glycomers than tumor cells. Thus, functionalized aryl beta-D-glycopyranosides represent a new class of molecules potentially able to control the progression of brain tumors.

CiteXplore: 12904064

DOI: 10.1021/jm0205853