Document Report Card

ID: ALA1145054

Journal: J Med Chem

Title: Enantioselective syntheses and cytotoxicity of N,O-nucleosides.

Authors: Chiacchio U, Corsaro A, Iannazzo D, Piperno A, Pistarà V, Rescifina A, Romeo R, Valveri V, Mastino A, Romeo G.

Abstract: Enantiomers of 4'-aza-2',3'-dideoxynucleosides have been prepared by two different synthetic approaches, on the basis of 1,3-dipolar cycloaddition of a chiral nitrone. Cytotoxicity and apoptotic activity have been investigated. (5'S)-5-Fluoro-1-isoxazolidin-5-yl-1H-pyrimidine-2,4-dione [(-)-AdFU], while showing low level of cytotoxicity, is a good inductor of apoptosis on lymphoid and monocytoid cells, acting as a strong potentiator of Fas-induced cell death.

CiteXplore: 12904074

DOI: 10.1021/jm0308186