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ID: ALA1145140
Journal: Bioorg Med Chem Lett
Title: Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Authors: Iwanowicz EJ, Watterson SH, Guo J, Pitts WJ, Murali Dhar TG, Shen Z, Chen P, Gu HH, Fleener CA, Rouleau KA, Cheney DL, Townsend RM, Hollenbaugh DL.
Abstract: The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogues) are given.
CiteXplore: 12781195