Document Report Card

ID: ALA1145208

Journal: J Med Chem

Title: 3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors.

Authors: Leung-Toung R, Tam TF, Wodzinska JM, Zhao Y, Lowrie J, Simpson CD, Karimian K, Spino M.

Abstract: A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 muM, compound 8 caused 50% reduction in fibrin gamma-chain cross-linking and suppressed the polymerization of alpha chains in platelet-depleted human plasma clots. Fibrinolysis rates in response to tissue plasminogen activator were directly proportional to the concentration of 8 in plasma at the time of clotting.

CiteXplore: 15801818

DOI: 10.1021/jm049221w