Document Report Card
Basic Information
ID: ALA1145273
Journal: Bioorg Med Chem Lett
Title: New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
Authors: Hosoya T, Yamamoto Y, Uehara Y, Hayashi M, Komiyama K, Ishibashi M.
Abstract: Two new bisindole alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3-10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity.
CiteXplore: 15911254