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ID: ALA1145275
Journal: Bioorg Med Chem Lett
Title: Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.
Authors: Xiao X, Miao ZH, Antony S, Pommier Y, Cushman M.
Abstract: Dihydroindenoisoquinolines are analogs of cytotoxic indenoisoquinoline topoisomerase I (Top1) inhibitors, exhibiting potent cytotoxicity but weak inhibitory activity toward Top1. Through COMPARE analysis, cytotoxicity studies in Top1-deficient cells, chemical synthesis and biological evaluation of methylated dihydroindenoisoquinoline 5, we demonstrated that dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines in cancer cells.
CiteXplore: 15911256