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ID: ALA1145361
Journal: Bioorg Med Chem Lett
Title: 3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.
Authors: Butora G, Jiao R, Parsons WH, Vicario PP, Jin H, Ayala JM, Cascieri MA, Yang L.
Abstract: A series of low molecular weight antagonists of both the human and murine CC chemokine receptor 2, containing a 1-alkyl-3-(3-methyl-4-spiroindenylpiperidine)-substituted cyclopentanecarboxamide, is described. A SAR study of the C(1) substituent revealed that short, branched alkyl groups such as isopropyl, isobutyl, or cyclopropyl are optimal for both human and murine CCR2 binding activity.
CiteXplore: 17482462