The discovery of long acting beta2-adrenoreceptor agonists.

ID: ALA1145365

Journal: Bioorg Med Chem Lett

Title: The discovery of long acting beta2-adrenoreceptor agonists.

Authors: Brown AD, Bunnage ME, Glossop PA, James K, Jones R, Lane CA, Lewthwaite RA, Mantell S, Perros-Huguet C, Price DA, Trevethick M, Webster R.

Abstract: The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.

CiteXplore: 17498952

DOI: 10.1016/j.bmcl.2007.04.081

Patent ID: ┄