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ID: ALA1145367
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.
Authors: Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL.
Abstract: We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
CiteXplore: 17498954