Basic Information
ID: ALA1145434
Journal: Bioorg Med Chem Lett
Title: Optimization of novel combi-molecules: identification of balanced and mixed bcr-abl/DNA targeting properties.
Authors: Rachid Z, Katsoulas A, Williams C, Larroque AL, McNamee J, Jean-Claude BJ.
Abstract: Steps toward the identification of combi-molecules with strong abl tyrosine kinase (TK) inhibitory property and significant DNA damaging potential are described. The optimized combi-molecule 13a was shown to induce approximately twofold stronger abl TK inhibitory activity than Gleevec and high levels of DNA damage in chronic myelogenous leukemic cells.
CiteXplore: 17572088
DOI: 10.1016/j.bmcl.2007.05.067
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets