Document Report Card

ID: ALA1145446

Journal: J Med Chem

Title: Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents.

Authors: Chiacchio U, Rescifina A, Iannazzo D, Piperno A, Romeo R, Borrello L, Sciortino MT, Balestrieri E, Macchi B, Mastino A, Romeo G.

Abstract: Phosphonated carbocyclic 2'-oxa-3'-azanucleosides have been synthesized and tested for their antiretroviral activity. The obtained results have shown that some of the compounds were as powerful as azydothymidine in inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virus type 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/lymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by human retroviruses.

CiteXplore: 17580846

DOI: 10.1021/jm070285r