Document Report Card

ID: ALA1145500

Journal: Antimicrob Agents Chemother

Title: In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci.

Authors: Llull D, Rivas L, García E.

Abstract: Miltefosine (hexadecylphosphocholine), the first oral drug against visceral leishmaniasis, triggered pneumococcal autolysis at concentrations higher than 2.5 microM. Bactericidal activity was also observed in cultures of other streptococci, although these failed to undergo lysis. The autolysis elicited by miltefosine can be attributed to triggering of the pneumococcal autolysin LytA.

CiteXplore: 17353242

DOI: 10.1128/aac.01428-06