Document Report Card

ID: ALA1145537

Journal: Antimicrob Agents Chemother

Title: Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters.

Authors: Aslam S, Trautner BW, Ramanathan V, Darouiche RO.

Abstract: To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

CiteXplore: 17220399

DOI: 10.1128/aac.00893-06