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ID: ALA1145577

Journal: Bioorg Med Chem Lett

Title: IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Authors: Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.

Abstract: Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.

CiteXplore: 18501603

DOI: 10.1016/j.bmcl.2008.04.042