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ID: ALA1145582
Journal: Bioorg Med Chem Lett
Title: 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.
Authors: Anupam R, Nayek A, Green NJ, Grundy FJ, Henkin TM, Means JA, Bergmeier SC, Hines JV.
Abstract: The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.
CiteXplore: 18502126