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ID: ALA1145628
Journal: Bioorg Med Chem Lett
Title: New tetrazole-based selective anandamide uptake inhibitors.
Authors: Ortar G, Schiano Moriello A, Cascio MG, De Petrocellis L, Ligresti A, Morera E, Nalli M, Di Marzo V.
Abstract: A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC(50)=2.3-5.1microM) and selectively over other proteins involved in endocannabinoid action and metabolism.
CiteXplore: 18424134