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ID: ALA1145637
Journal: Bioorg Med Chem Lett
Title: Dual binding site inhibitors of B-RAF kinase.
Authors: Wolin RL, Bembenek SD, Wei J, Crawford S, Lundeen K, Brunmark A, Karlsson L, Edwards JP, Blevitt JM.
Abstract: Computer aided modeling guided the design of a series of diarylimidazole compounds (11-22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
CiteXplore: 18434146