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ID: ALA1145725
Journal: Bioorg Med Chem Lett
Title: Synthesis and antimicrobial activity of novel globomycin analogues.
Authors: Kiho T, Nakayama M, Yasuda K, Miyakoshi S, Inukai M, Kogen H.
Abstract: Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
CiteXplore: 12824025