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ID: ALA1145762
Journal: Bioorg Med Chem Lett
Title: Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
Authors: Kuo RY, Wu CC, Chang FR, Yeh JL, Chen IJ, Wu YC.
Abstract: Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.
CiteXplore: 12617899