Document Report Card

ID: ALA1145845

Journal: J Med Chem

Title: Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.

Authors: Nakanishi Y, Chang FR, Liaw CC, Wu YC, Bastow KF, Lee KH.

Abstract: Several bioactive acetogenins were selective against 1A9 (ovarian cancer) cell replication but did not show a corresponding hyperactivity against other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for other cell lines.

CiteXplore: 12852747

DOI: 10.1021/jm020548b