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ID: ALA1145867
Journal: Bioorg Med Chem Lett
Title: Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.
Authors: Yamashita A, Norton E, Petersen PJ, Rasmussen BA, Singh G, Yang Y, Mansour TS, Ho DM.
Abstract: A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
CiteXplore: 12951123