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ID: ALA1145874
Journal: Bioorg Med Chem Lett
Title: Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Authors: Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR.
Abstract: A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.
CiteXplore: 12951078