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ID: ALA1145881
Journal: Bioorg Med Chem Lett
Title: Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Authors: Hasvold LA, Wang W, Gwaltney SL, Rockway TW, Nelson LT, Mantei RA, Fakhoury SA, Sullivan GM, Li Q, Lin NH, Wang L, Zhang H, Cohen J, Gu WZ, Marsh K, Bauch J, Rosenberg S, Sham HL.
Abstract: Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.
CiteXplore: 14592494