Document Report Card

ID: ALA1145901

Journal: J Med Chem

Title: A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.

Authors: Vázquez MJ, Roa AM, Reyes F, Vega A, Rivera-Sagredo A, Thomas DR, Díez E, Hueso-Rodríguez JA.

Abstract: In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This compound has a pK(i) of 10.2 versus the 5-hydroxytryptamine(1A) receptor subtype. The structure was elucidated by extensive NMR spectroscopy and mass spectrometry.

CiteXplore: 14613313

DOI: 10.1021/jm0341204