Document Report Card

ID: ALA1145902

Journal: J Med Chem

Title: Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.

Authors: Xu Y, Mayhugh D, Saeed A, Wang X, Thompson RC, Dominianni SJ, Kauffman RF, Singh J, Bean JS, Bensch WR, Barr RJ, Osborne J, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Huang N, Luffer-Atlas D, Rungta D, Maise DE, Mantlo NB.

Abstract: A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.

CiteXplore: 14613314

DOI: 10.1021/jm034173l