Document Report Card

ID: ALA1145952

Journal: J Med Chem

Title: Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Authors: Colletti SL, Frie JL, Dixon EC, Singh SB, Choi BK, Scapin G, Fitzgerald CE, Kumar S, Nichols EA, O'Keefe SJ, O'Neill EA, Porter G, Samuel K, Schmatz DM, Schwartz CD, Shoop WL, Thompson CM, Thompson JE, Wang R, Woods A, Zaller DM, Doherty JB.

Abstract: Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.

CiteXplore: 12540232

DOI: 10.1021/jm025585h