Document Report Card

ID: ALA1145969

Journal: J Med Chem

Title: New semisynthetic quassinoids with in vivo antimalarial activity.

Authors: Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim HS, Begum K, Wataya Y, Kobayashi M.

Abstract: On the basis of a comparative analysis for stability in mouse serum between 15-O-acetylbruceolide and bruceolide 15-methyl carbonate, several 3,15-dialkyl carbonates of bruceolide were synthesized and their in vitro antimalarial activity was assessed. Methyl, ethyl, and isopropyl carbonates with pronounced in vitro activity were further evaluated for in vivo antimalarial potency. Both the methyl and ethyl carbonates significantly increased the life span of mice as compared with 3,15-di-O-accetylbruceolide and chloroquine.

CiteXplore: 12570385

DOI: 10.1021/jm0201971