Document Report Card
Basic Information
ID: ALA1146049
Journal: Bioorg Med Chem Lett
Title: Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity.
Authors: Auvin S, Pignol B, Navet E, Troadec M, Carré D, Camara J, Bigg D, Chabrier PE.
Abstract: A series of dipeptides with dual inhibitory activities on calpain and lipid peroxidation were prepared to target the intracellular calpain. This optimization program focused on the variations of the linker and the N-terminal amino acid of the peptidic core. Two compounds 6d-05 and 6d-08 exhibited potent intracellular calpain inhibition. The polar surface area and the number of rotors appeared to be critical descriptors to account for the behavior of these hybrid molecules in the cellular calpain assay.
CiteXplore: 16380258