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ID: ALA1146109

Journal: Bioorg Med Chem Lett

Title: Small molecule inhibitors of plasma kallikrein.

Authors: Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J.

Abstract: Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the pharmacokinetics of a lead analog 11 in rat.

CiteXplore: 16413183

DOI: 10.1016/j.bmcl.2005.12.060