Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.

ID: ALA1146157

Journal: Bioorg Med Chem Lett

Title: Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.

Authors: Feng D, Fisher M, Liang GB, Qian X, Brown C, Gurnett A, Leavitt PS, Liberator PA, Mathew J, Misura A, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T.

Abstract: Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.

CiteXplore: 17000105

DOI: 10.1016/j.bmcl.2006.08.127

Patent ID: ┄