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ID: ALA1146162
Journal: Bioorg Med Chem Lett
Title: Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
Authors: Richards S, Sorensen B, Jae HS, Winn M, Chen Y, Wang J, Fung S, Monzon K, Frevert EU, Jacobson P, Sham H, Link JT.
Abstract: High throughput screening efforts have identified a novel class of dichloroaniline amide 11beta-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4 focused on retaining the potency and selectivity profile of the lead.
CiteXplore: 17000111