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ID: ALA1146175
Journal: Bioorg Med Chem Lett
Title: Natural inhibitors targeting osteoclast-mediated bone resorption.
Authors: Zeng GZ, Tan NH, Hao XJ, Mu QZ, Li RT.
Abstract: Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.
CiteXplore: 17027271